Journal article icon

Journal article

Determining the molecular basis for the pH-dependent interaction between the link module of human TSG-6 and hyaluronan.

Abstract:

TSG-6 is an inflammation-associated hyaluronan (HA)-binding protein that has anti-inflammatory and protective functions in arthritis and asthma as well as a critical role in mammalian ovulation. The interaction between TSG-6 and HA is pH-dependent, with a marked reduction in affinity on increasing the pH from 6.0 to 8.0. Here we have investigated the mechanism underlying this pH dependence using a combined approach of site-directed mutagenesis, NMR, isothermal titration calorimetry and microt...

Expand abstract

Actions


Access Document


Publisher copy:
10.1074/jbc.m611713200

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of biological chemistry More from this journal
Volume:
282
Issue:
17
Pages:
12976-12988
Publication date:
2007-04-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Language:
English
Keywords:
Pubs id:
pubs:95166
UUID:
uuid:9137ef80-f4eb-4b3b-99c7-6e66f98cf411
Local pid:
pubs:95166
Source identifiers:
95166
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP