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Determining the molecular basis for the pH-dependent interaction between the link module of human TSG-6 and hyaluronan.

Abstract:

TSG-6 is an inflammation-associated hyaluronan (HA)-binding protein that has anti-inflammatory and protective functions in arthritis and asthma as well as a critical role in mammalian ovulation. The interaction between TSG-6 and HA is pH-dependent, with a marked reduction in affinity on increasing the pH from 6.0 to 8.0. Here we have investigated the mechanism underlying this pH dependence using a combined approach of site-directed mutagenesis, NMR, isothermal titration calorimetry and microt...

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Publisher copy:
10.1074/jbc.m611713200

Authors


Blundell, CD More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Cordell, MR More by this author
Kahmann, JD More by this author
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Journal:
The Journal of biological chemistry
Volume:
282
Issue:
17
Pages:
12976-12988
Publication date:
2007-04-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:9137ef80-f4eb-4b3b-99c7-6e66f98cf411
Source identifiers:
95166
Local pid:
pubs:95166

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