Journal article icon

Journal article

Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity.

Abstract:

The cell wall of gram-positive bacteria is a complex network of surface proteins, capsular polysaccharides and wall teichoic acids (WTA) covalently linked to Peptidoglycan (PG). The absence of WTA has been associated with a reduced pathogenicity of Staphylococcus aureus (S. aureus). Here, we assessed whether this was due to increased detection of PG, an important target of innate immune receptors. Antibiotic-mediated or genetic inhibition of WTA production in S. aureus led to increased bindin...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.ppat.1002421

Authors


More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Funding agency for:
Ligoxygakis, P
Grant:
WT087680
More from this funder
Funding agency for:
Ligoxygakis, P
Grant:
WT087680
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathog Journal website
Volume:
7
Issue:
12
Article number:
e1002421
Publication date:
2011-12-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
216147
Language:
English
Keywords:
Pubs id:
pubs:216147
UUID:
uuid:9129cf0e-6ceb-48ad-8834-bf51aed643bd
Local pid:
pubs:216147
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP