Journal article

The midbrain periaqueductal gray as an integrative and interoceptive neural structure for breathing

Abstract:: The periaqueductal gray (PAG) plays a critical role in autonomic function and behavioural responses to threatening stimuli. Recent evidence has revealed the PAG's potential involvement in the perception of breathlessness, a highly threatening respiratory symptom. In this review, we outline the current evidence in animals and humans on the role of the PAG in respiratory control and in the perception of breathlessness. While recent work has unveiled dissociable brain activity within the lateral PAG during perception of breathlessness and ventrolateral PAG during conditioned anticipation in healthy humans, this is yet to be translated into diseases dominated by breathlessness symptomology, such as chronic obstructive pulmonary disease. Understanding how the sub-structures of the PAG differentially interact with interoceptive brain networks involved in the perception of breathlessness will help towards understanding discordant symptomology, and may reveal treatment targets for those debilitated by chronic and pervasive breathlessness.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Faull, O., Subramanian, H., Ezra, M., & Pattinson, K. (2019). The midbrain periaqueductal gray as an integrative and interoceptive neural structure for breathing. Neuroscience and Biobehavioral Reviews, 98, 135–144.

MLA Style

Faull, O., et al. “The Midbrain Periaqueductal Gray as an Integrative and Interoceptive Neural Structure for Breathing.” Neuroscience and Biobehavioral Reviews, vol. 98, Elsevier, 2019, pp. 135–44.

Chicago Style

Faull, O, H Subramanian, M Ezra, and K Pattinson. 2019. “The Midbrain Periaqueductal Gray as an Integrative and Interoceptive Neural Structure for Breathing.” Neuroscience and Biobehavioral Reviews 98: 135–44.
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Files:: 2019_faull_PAG_review.pdf

(Preview, Version of record, pdf, 1.7MB, Terms of use)

Publisher copy:: 10.1016/j.neubiorev.2018.12.020

Authors

+ Faull, O More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Clinical Neurosciences
Role:: Author

+ Subramanian, H More by this author

Role:: Author

+ Ezra, M More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Clinical Neurosciences
Oxford college:: Green Templeton College
Role:: Author

+ Pattinson, K More by this author

Institution:: University of Oxford
Division:: Medical Sciences Division
Department:: Clinical Neurosciences
Role:: Author

Publisher:: Elsevier
Journal:: Neuroscience and Biobehavioral Reviews More from this journal
Volume:: 98
Pages:: 135-144
Publication date:: 2019-01-03
Acceptance date:: 2018-12-18
DOI:: 10.1016/j.neubiorev.2018.12.020
EISSN:: 1873-7528
ISSN:: 0149-7634

Keywords:: periaqueductal gray

interoception

breathlessness

respiration
Pubs id:: pubs:965413
UUID:: uuid:90fccb32-449c-40f2-a16a-f0d39f44b0b2
Local pid:: pubs:965413
Source identifiers:: 965413
Deposit date:: 2019-01-28

Terms of use

Copyright holder:: Faull et al
Copyright date:: 2019
Notes:: © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).

Licence:: CC Attribution (CC BY)

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