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Journal article

Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index.

Abstract:

Genetic studies have shown that obesity risk is heritable and that, of the many common variants now associated with body mass index, those in an intron of the fat mass and obesity-associated (FTO) gene have the largest effect. The size of the UK Biobank, and its joint measurement of genetic, anthropometric and lifestyle variables, offers an unprecedented opportunity to assess gene-by-environment interactions in a way that accounts for the dependence between different factors. We jointly exami...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms12724

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Oxford college:
St Annes College
Role:
Author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Pages:
12724
Publication date:
2016-09-05
Acceptance date:
2016-07-12
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:634676
URN:
uri:90dc0d59-a7fb-4d1f-b133-6b65feac3745
UUID:
uuid:90dc0d59-a7fb-4d1f-b133-6b65feac3745
Local pid:
pubs:634676
Language:
English
Keywords:

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