Journal article
Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index.
- Abstract:
- Genetic studies have shown that obesity risk is heritable and that, of the many common variants now associated with body mass index, those in an intron of the fat mass and obesity-associated (FTO) gene have the largest effect. The size of the UK Biobank, and its joint measurement of genetic, anthropometric and lifestyle variables, offers an unprecedented opportunity to assess gene-by-environment interactions in a way that accounts for the dependence between different factors. We jointly examine the evidence for interactions between FTO (rs1421085) and various lifestyle and environmental factors. We report interactions between the FTO variant and each of: frequency of alcohol consumption (P=3.0 × 10(-4)); deviations from mean sleep duration (P=8.0 × 10(-4)); overall diet (P=5.0 × 10(-6)), including added salt (P=1.2 × 10(-3)); and physical activity (P=3.1 × 10(-4)).
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 423.2KB, Terms of use)
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- Publisher copy:
- 10.1038/ncomms12724
Authors
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Communications More from this journal
- Volume:
- 7
- Pages:
- 12724
- Publication date:
- 2016-09-01
- Acceptance date:
- 2016-07-12
- DOI:
- EISSN:
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2041-1723
- ISSN:
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2041-1723
- Pmid:
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27596730
- Language:
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English
- Keywords:
- Pubs id:
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pubs:634676
- UUID:
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uuid:90dc0d59-a7fb-4d1f-b133-6b65feac3745
- Local pid:
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pubs:634676
- Source identifiers:
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634676
- Deposit date:
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2017-12-21
- ARK identifier:
Terms of use
- Copyright holder:
- Donnelly et al
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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