Journal article icon

Journal article

The effects of host contact network structure on pathogen diversity and strain structure.

Abstract:

For many important pathogens, mechanisms promoting antigenic variation, such as mutation and recombination, facilitate immune evasion and promote strain diversity. However, mathematical models have shown that host immune responses to polymorphic antigens can structure pathogen populations into discrete strains with nonoverlapping antigenic repertoires, despite recombination. Until now, models of strain evolution incorporating host immunity have assumed a randomly mixed host population. Here, ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.0402000101

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
29
Pages:
10839-10844
Publication date:
2004-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:90c4d985-a6b0-4d91-b1d0-8e5d045b7fd7
Source identifiers:
209729
Local pid:
pubs:209729

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP