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Sialic acid transport in Haemophilus influenzae is essential for lipopolysaccharide sialylation and serum resistance and is dependent on a novel tripartite ATP-independent periplasmic transporter.

Abstract:

Sialylation of the lipopolysaccharide (LPS) is an important mechanism used by the human pathogen Haemophilus influenzae to evade the innate immune response of the host. We have demonstrated that N-acetylneuraminic acid (Neu5Ac or sialic acid) uptake in H. influenzae is essential for the subsequent modification of the LPS and that this uptake is mediated through a single transport system which is a member of the tripartite ATP-independent periplasmic (TRAP) transporter family. Disruption of ei...

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Publication status:
Published

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Journal:
Molecular microbiology
Volume:
58
Issue:
4
Pages:
1173-1185
Publication date:
2005-11-05
DOI:
EISSN:
1365-2958
ISSN:
0950-382X
URN:
uuid:90a43c5c-60a4-47e5-bc76-7c641263abf2
Source identifiers:
115586
Local pid:
pubs:115586

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