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Synthesis of modified proteins via functionalization of dehydroalanine

Abstract:

Dehydroalanine has emerged in recent years as a non-proteinogenic residue with strong chemical utility in proteins for the study of biology. In this review we cover the several methods now available for its flexible and site-selective incorporation via a variety of complementary chemical and biological techniques and examine its reactivity, allowing both creation of modified protein side-chains through a variety of bond-forming methods (C-S, C-N, C-Se, C-C) and as an activity-based probe in i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.cbpa.2018.05.022

Authors


Dadová, J More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Oxford college:
Pembroke College
ORCID:
0000-0002-5056-407X
Publisher:
Elsevier Publisher's website
Journal:
Current Opinion in Chemical Biology Journal website
Volume:
46
Pages:
71-81
Publication date:
2018-06-15
Acceptance date:
2018-05-29
DOI:
EISSN:
1879-0402
ISSN:
1367-5931
Pubs id:
pubs:859660
URN:
uri:90893143-96c8-4f50-ad6b-b0086ca00737
UUID:
uuid:90893143-96c8-4f50-ad6b-b0086ca00737
Local pid:
pubs:859660
Language:
English
Keywords:

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