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Relative proximity of chromosome territories influences chromosome exchange partners in radiation-induced chromosome rearrangements in primary human bronchial epithelial cells and in a small cell lung cancer cell line

Abstract:

It is well established that chromosomes exist in discrete territories (CTs) in interphase and are positioned in a cell-type specific probabilistic manner. The relative localisation of individual CTs within cell nuclei remains poorly understood, yet many cancers are associated with specific chromosome rearrangements and there is good evidence that relative territorial position influences their frequency of exchange. To examine this further, we characterised the complexity of radiation-induced ...

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Publication status:
Published

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Authors


Garimberti, E More by this author
Estrada, GG More by this author
Arsuaga, J More by this author
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Journal:
MUTAGENESIS
Volume:
27
Issue:
1
Pages:
118-119
Publication date:
2012-01-05
DOI:
EISSN:
1879-3592
ISSN:
0267-8357
URN:
uuid:9080dd92-499e-4bfc-9e6a-dcd29f59f78e
Source identifiers:
323847
Local pid:
pubs:323847

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