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JAK1 selective inhibitors for the treatment of spondyloarthropathies

Abstract:

As our understanding of the pathogenesis of spondyloarthropathies improves, focus has turned to the role janus kinase (JAK) mediated signal transduction and inhibiting its actions as a therapeutic mechanism. Small molecule inhibitors of JAK exist, with variable selectivity for the different JAK isoforms. Less selective JAK inhibitors have variable efficacy and safety profiles, prompting the investigation of selective JAK1 inhibition. In this review, we summarise the current phase 2 and 3 clin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Role:
Author
ORCID:
0000-0002-4756-663X
Publisher:
Oxford University Press
Journal:
Rheumatology More from this journal
Volume:
60
Issue:
S2
Pages:
ii39-ii44
Publication date:
2021-05-05
Acceptance date:
2020-11-03
DOI:
EISSN:
1462-0332
ISSN:
1462-0324
Language:
English
Keywords:
Pubs id:
1140320
Local pid:
pubs:1140320
Deposit date:
2020-11-03

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