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CD200 and membrane protein interactions in the control of myeloid cells.

Abstract:

OX2 (now designated CD200) is a membrane protein expressed by a broad range of cell types. It is the ligand for a receptor restricted to myeloid cells, with the potential to deliver inhibitory signals. This is indicated by the CD200-deficient mouse model, in which myeloid cells are more activated when stimulated immunologically than cells from normal mice. The unusual tissue distribution of CD200 indicates where myeloid cells can be restrictively controlled through cell-cell contact. Recent d...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Wright, GJ More by this author
Journal:
Trends in immunology
Volume:
23
Issue:
6
Pages:
285-290
Publication date:
2002-06-05
DOI:
EISSN:
1471-4981
ISSN:
1471-4906
URN:
uuid:906c20fe-9e57-4252-83e9-ab4e84963baf
Source identifiers:
28523
Local pid:
pubs:28523

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