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Journal article

Clusterin is required for β-Amyloid toxicity in human iPSC-derived neurons

Abstract:

Our understanding of the molecular processes underlying Alzheimer's disease (AD) is still limited, hindering the development of effective treatments, and highlighting the need for human-specific models. Advances in identifying components of the amyloid cascade are progressing, including the role of the protein clusterin in mediating β-amyloid (Aβ) toxicity. Mutations in the clusterin gene (CLU), a major genetic AD risk factor, are known to have important roles in Aβ processing. Here we invest...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More from this funder
Name:
Medical Research Council
Grant:
1246016
Publisher:
Frontiers Media
Journal:
Frontiers in Neuroscience More from this journal
Volume:
12
Pages:
504
Publication date:
2018-07-25
Acceptance date:
2018-07-04
DOI:
ISSN:
1662-453X and 1662-4548
Pmid:
30090055
Language:
English
Keywords:
Pubs id:
pubs:894268
UUID:
uuid:90357f86-4f85-42c4-bab6-5bc583c5cd7f
Local pid:
pubs:894268
Source identifiers:
894268
Deposit date:
2018-08-28

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