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Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones.

Abstract:
The utilization of sequential palladium-catalyzed α-arylation and cyclization reactions provides a general approach to an array of isoquinolines and their corresponding N-oxides. This methodology allows the convergent combination of readily available precursors in a regioselective manner and in excellent overall yields. This powerful route to polysubstituted isoquinolines, which is not limited to electron rich moieties, also allows rapid access to analogues of biologically active compounds.
Publication status:
Published

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Publisher copy:
10.1073/pnas.1206532109

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
109
Issue:
29
Pages:
11605-11608
Publication date:
2012-07-02
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:341080
UUID:
uuid:9000f89e-3609-497f-9094-bf760f49c226
Local pid:
pubs:341080
Source identifiers:
341080
Deposit date:
2013-11-16

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