Journal article

Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones.

Abstract:: The utilization of sequential palladium-catalyzed α-arylation and cyclization reactions provides a general approach to an array of isoquinolines and their corresponding N-oxides. This methodology allows the convergent combination of readily available precursors in a regioselective manner and in excellent overall yields. This powerful route to polysubstituted isoquinolines, which is not limited to electron rich moieties, also allows rapid access to analogues of biologically active compounds.

Publication status:: Published

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APA Style

Donohoe, T., Pilgrim, B., Jones, G., & Bassuto, J. (2012). Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones. Proceedings of the National Academy of Sciences of the United States of America, 109(29), 11605–11608.

MLA Style

Donohoe, T., et al. “Synthesis of Substituted Isoquinolines Utilizing Palladium-Catalyzed α-Arylation of Ketones.” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 29, 2012, pp. 11605–08.

Chicago Style

Donohoe, T, B Pilgrim, G Jones, and J Bassuto. 2012. “Synthesis of Substituted Isoquinolines Utilizing Palladium-Catalyzed α-Arylation of Ketones.” Proceedings of the National Academy of Sciences of the United States of America 109 (29): 11605–8.
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Publisher copy:: 10.1073/pnas.1206532109

Authors

+ Donohoe, T More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Pilgrim, B More by this author

Role:: Author

+ Jones, G More by this author

Role:: Author

+ Bassuto, J More by this author

Role:: Author

Journal:: Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:: 109
Issue:: 29
Pages:: 11605-11608
Publication date:: 2012-07-02
DOI:: 10.1073/pnas.1206532109
EISSN:: 1091-6490
ISSN:: 0027-8424

Language:: English
Keywords:: Catalysis

Ketones

Isoquinolines

Molecular Structure

Palladium
Pubs id:: pubs:341080
UUID:: uuid:9000f89e-3609-497f-9094-bf760f49c226
Local pid:: pubs:341080
Source identifiers:: 341080
Deposit date:: 2013-11-16

Terms of use

Copyright date:: 2012

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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