Journal article icon

Journal article

A transcription cofactor required for the heat-shock response.

Abstract:

The Stress-responsive activator of p300 (Strap) is a transcription cofactor that has an important role in the control of DNA damage response through its ability to regulate p53 activity. Here, we report that Strap is inducible by heat shock and stimulates the transcription of heat-shock genes. A chromatin-associated complex involving heat-shock factor 1 (HSF1), Strap and the p300 coactivator assembles on the heat-shock protein 70 (hsp70) promoter, and Strap augments HSF1 binding and chromatin...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/embor.2008.70
Journal:
EMBO reports More from this journal
Volume:
9
Issue:
7
Pages:
662-669
Publication date:
2008-07-01
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
Language:
English
Keywords:
Pubs id:
pubs:261800
UUID:
uuid:8ffa7baa-b7c4-4349-9253-acbd662f36e6
Local pid:
pubs:261800
Source identifiers:
261800
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP