Chiral epoxides by desymmetrizing deprotonation of meso-epoxides.
- Simple meso-epoxides can be asymmetrically functionalized: Ligand-assisted direct hydrogen-lithium exchange allows the generation of destabilized oxiranyl lithium species and their subsequent trapping by a wide array of electrophiles (see scheme; E = group formed by addition of electrophile). When carried out in the presence of (-)-sparteine as ligand, this reaction provides a new enantioselective route to epoxides.
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- Angewandte Chemie (International ed. in English)
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