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Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.

Abstract:

Siglecs are sialic acid-recognizing animal lectins of the immunoglobulin superfamily. We have cloned and characterized a novel human molecule, Siglec-11, that belongs to the subgroup of CD33/Siglec-3-related Siglecs. As with others in this subgroup, the cytosolic domain of Siglec-11 is phosphorylated at tyrosine residue(s) upon pervanadate treatment of cells and then recruits the protein-tyrosine phosphatases SHP-1 and SHP-2. However, Siglec-11 has several novel features relative to the other...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m202833200

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
Crocker, PR More by this author
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Journal:
The Journal of biological chemistry
Volume:
277
Issue:
27
Pages:
24466-24474
Publication date:
2002-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:8fcd727f-165a-4f55-acd5-60cf528f109e
Source identifiers:
21511
Local pid:
pubs:21511

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