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Journal article

Paternal effect of the nuclear formin-like protein MISFIT on Plasmodium development in the mosquito vector.

Abstract:

Malaria parasites must undergo sexual and sporogonic development in mosquitoes before they can infect their vertebrate hosts. We report the discovery and characterization of MISFIT, the first protein with paternal effect on the development of the rodent malaria parasite Plasmodium berghei in Anopheles mosquitoes. MISFIT is expressed in male gametocytes and localizes to the nuclei of male gametocytes, zygotes and ookinetes. Gene disruption results in mutant ookinetes with reduced genome conten...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1000539

Authors


Bushell, ES More by this author
Schlegelmilch, T More by this author
Goulding, D More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
5
Issue:
8
Pages:
e1000539
Publication date:
2009-08-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:8fbf0926-371b-4bd8-8ac7-af224507dce0
Source identifiers:
266491
Local pid:
pubs:266491

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