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Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine

Abstract:

The cellular mechanism(s) linking macrophages to norepinephrine (NE)-mediated regulation of thermogenesis have been a topic of debate. Here we identify sympathetic neuron-associated macrophages (SAMs) as a population of cells that mediate clearance of NE via expression of solute carrier family 6 member 2 (SLC6A2), an NE transporter, and monoamine oxidase A (MAOA), a degradation enzyme. Optogenetic activation of the sympathetic nervous system (SNS) upregulates NE uptake by SAMs and shifts the ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/nm.4422

Authors


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ORCID:
0000-0003-2314-0439
More by this author
ORCID:
0000-0003-2819-2051
Seidman, JS More by this author
Sánchez, NM More by this author
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Fundação para a Ciéncia e Tecnologia More from this funder
European Molecular Biology Organization More from this funder
Human Frontier Science Program More from this funder
Maratona da Saúde More from this funder
National Institutes of Health More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Medicine Journal website
Volume:
23
Issue:
1
Pages:
1309–1318
Publication date:
2017-10-09
Acceptance date:
2017-09-12
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Pubs id:
pubs:864441
URN:
uri:8fa8f790-9f00-4c2f-8749-804fd67157e9
UUID:
uuid:8fa8f790-9f00-4c2f-8749-804fd67157e9
Local pid:
pubs:864441

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