Journal article icon

Journal article

Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS).

Abstract:

Deacetoxycephalosporin C synthase (DAOCS) is an iron(II) and 2-oxoglutarate-dependent oxygenase that catalyzes the conversion of penicillin N to deacetoxycephalosporin C, the committed step in the biosynthesis of cephalosporin antibiotics. The crystal structure of DAOCS revealed that the C terminus of one molecule is inserted into the active site of its neighbor in a cyclical fashion within a trimeric unit. This arrangement has hindered the generation of crystalline enzyme-substrate complexes...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1006/jmbi.2001.4649

Authors


Clifton, IJ More by this author
Baldwin, JE More by this author
Expand authors...
Journal:
Journal of molecular biology
Volume:
308
Issue:
5
Pages:
937-948
Publication date:
2001-05-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:8f7be0e7-bb26-485f-af50-d3e04ce772fa
Source identifiers:
31877
Local pid:
pubs:31877

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP