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Does variation in neurodegenerative disease susceptibility and phenotype reflect cerebral differences at the network level?

Abstract:

Alzheimer's disease (AD) is 10-fold more frequent than Parkinson's disease (PD), which in turn is 10-fold more frequent than amyotrophic lateral sclerosis (ALS). The differences between these neurodegenerative diseases have been ascribed to a selective vulnerability of specific neuronal sub-types that then determine each disorder. However, there are non-neuronal cells that are ubiquitously and possibly primarily involved in all of them, and they share regulatory mechanisms through similar int...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Amyotrophic lateral sclerosis and frontotemporal degeneration
Volume:
14
Issue:
7-8
Pages:
487-493
Publication date:
2013-12-05
DOI:
EISSN:
2167-9223
ISSN:
2167-8421
URN:
uuid:8f2c8809-da1f-471d-9f89-04a25b6e7739
Source identifiers:
441082
Local pid:
pubs:441082

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