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Mapping a multiplexed zoo of mRNA expression

Abstract:

In situ hybridization methods are used across the biological sciences to map mRNA expression within intact specimens. Multiplexed experiments, in which multiple target mRNAs are mapped in a single sample, are essential for studying regulatory interactions, but remain cumbersome in most model organisms. Programmable in situ amplifiers based on the mechanism of hybridization chain reaction (HCR) overcome this longstanding challenge by operating independently within a sample, enabling multiplexe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dev.140137

Authors


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Role:
Author
ORCID:
0000-0002-1530-0773
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Name:
Medical Research Council
Grant:
G0902418
G1000801
Publisher:
The Company of Biologists
Journal:
Development More from this journal
Volume:
143
Issue:
19
Pages:
3632-3637
Place of publication:
England
Publication date:
2016-10-04
Acceptance date:
2016-08-01
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Pmid:
27702788
Language:
English
Keywords:
Pubs id:
652005
Local pid:
pubs:652005
Deposit date:
2020-06-09

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