Selective requirements for NRP1 ligands during neurovascular patterning.

Journal article

Blood vessels and neurons share several types of guidance cues and cell surface receptors to control their behaviour during embryogenesis. The transmembrane protein NRP1 is present on blood vessels and nerves. NRP1 binds two structurally diverse ligands, the semaphorin SEMA3A and the VEGF164 isoform of vascular endothelial growth factor. SEMA3A was originally identified as a repulsive cue for developing axons that acts by signalling through receptor complexes containing NRP1 and plexins. In v...

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Authors: Vieira, J; Schwarz, Q; Ruhrberg, C

• Journal: Development (Cambridge, England)
• Volume: 134
• Issue: 10
• Pages: 1833-1843
• Publication date: 2007-05-01
• DOI: 10.1242/dev.002402
• EISSN: 1477-9129
• ISSN: 0950-1991
• Language: English
• Keywords: Axons; Body Patterning; Semaphorins; Animals; Neovascularization, Physiologic; Mice; Mice, Inbred C57BL; Vascular Endothelial Growth Factor A; Ligands; Neurons; Semaphorin-3A; Gene Expression Regulation, Developmental; Neuropilins; Neuropilin-1