Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology.

Journal article

PURPOSE: To investigate fundus autofluorescence (AF) characteristics in the Abca4(-/-) mouse, an animal model for AMD and Stargardt disease, and to correlate findings with functional, structural, and biochemical assessments. METHODS: Blue (488 nm) and near-infrared (790 nm) fundus AF images were quantitatively and qualitatively analyzed in pigmented Abca4(-/-) mice and wild type (WT) controls in vivo. Functional, structural, and biochemical assessments included electroretinography (ERG), lig...

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Authors: Charbel Issa, P; Barnard, A; Singh, MS; Carter, E; Jiang, Z

• Publication status: Published
• Journal: Investigative ophthalmology and visual science
• Volume: 54
• Issue: 8
• Pages: 5602-5612
• Publication date: 2013-01-01
• DOI: 10.1167/iovs.13-11688
• EISSN: 1552-5783
• ISSN: 0146-0404
• Language: English
• Keywords: Fundus Oculi; Disease Models, Animal; Macular Degeneration; Optical Imaging; Lipofuscin; Retinal Pigment Epithelium; Mice, Knockout; Microscopy, Electron, Transmission; Animals; Retinal Dystrophies; Cytoplasmic Granules; Dark Adaptation; ATP-Binding Cassette Transporters; Pyridinium Compounds; Retinoids; Mice; Electroretinography; Genes, Recessive