Journal article icon

Journal article

Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology.

Abstract:

PURPOSE: To investigate fundus autofluorescence (AF) characteristics in the Abca4(-/-) mouse, an animal model for AMD and Stargardt disease, and to correlate findings with functional, structural, and biochemical assessments. METHODS: Blue (488 nm) and near-infrared (790 nm) fundus AF images were quantitatively and qualitatively analyzed in pigmented Abca4(-/-) mice and wild type (WT) controls in vivo. Functional, structural, and biochemical assessments included electroretinography (ERG), lig...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1167/iovs.13-11688

Authors


Charbel Issa, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Expand authors...
Journal:
Investigative ophthalmology and visual science
Volume:
54
Issue:
8
Pages:
5602-5612
Publication date:
2013
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
URN:
uuid:8f01eef7-658b-46df-bd48-9de2a0230e72
Source identifiers:
407848
Local pid:
pubs:407848

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP