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Randomized controlled trials for schizophrenia: study designs targeted to distinct goals.

Abstract:

Randomized controlled trials for antipsychotic drugs have a variety of design features suited to diverse purposes. Efficacy (or explanatory) trials seek to establish if a drug can reduce psychotic symptoms under ideal circumstances. To isolate drug effects, researchers enroll carefully selected patients. Specialized research personnel use rating scales of symptoms that are sensitive to drug effects as the study primary outcomes. Large simple trials (LSTs) are conducted at typical treatment se...

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Publication status:
Published

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Publisher copy:
10.1093/schbul/sbm156

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
Schizophrenia bulletin
Volume:
34
Issue:
2
Pages:
266-274
Publication date:
2008-03-05
DOI:
EISSN:
1745-1701
ISSN:
0586-7614
URN:
uuid:8ef587f1-aab9-4927-80c0-8a8190a0a8ca
Source identifiers:
127571
Local pid:
pubs:127571

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