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Can intravenous endothelin-1 be used to enhance hypoxic pulmonary vasoconstriction in healthy humans?

Abstract:

BACKGROUND: Hypoxic pulmonary vasoconstriction (HPV) helps match pulmonary perfusion to ventilation. The peptide endothelin-1 (ET-1) may be involved in the cellular mechanisms of this response. We hypothesized that increasing plasma ET-1 concentration during hypoxia would enhance HPV in humans and might represent a strategy for improving gas exchange during single-lung anaesthesia or respiratory disease. METHODS: Nine healthy volunteers were each exposed twice to a 7-h protocol consisting of...

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Publication status:
Published

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Publisher copy:
10.1093/bja/aen214

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
British journal of anaesthesia More from this journal
Volume:
101
Issue:
4
Pages:
466-472
Publication date:
2008-10-01
DOI:
EISSN:
1471-6771
ISSN:
0007-0912
Language:
English
Keywords:
Pubs id:
pubs:114237
UUID:
uuid:8ef02fe8-344b-4a0f-aaa0-f5ed922ffd66
Local pid:
pubs:114237
Source identifiers:
114237
Deposit date:
2012-12-19

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