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The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparum.

Abstract:

Epidemiological observations suggest that T cell immunity may be suppressed in malaria-endemic areas. In vitro studies, animal models, and limited data in humans link immunosuppression with malaria, malnutrition, and other parasitic infections. However, there are no data to determine whether malaria-induced immunosuppression is significant in the long-term, or relative data comparing it with other factors in malaria-endemic areas, so as to measure the impact of malaria, other parasitic diseas...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.179.6.4193

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
179
Issue:
6
Pages:
4193-4201
Publication date:
2007-09-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:8ee7fe9a-ffd9-44ba-a7dd-6012723bc8c2
Source identifiers:
40474
Local pid:
pubs:40474

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