The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparum.

Bejon, P; Mwacharo, J; Kai, O; Todryk, S; Keating, S; Lowe, B; Lang, T; Mwangi, T; Gilbert, S; Peshu, N; Marsh, K; Hill, A

Journal article

The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparum.

Abstract:: Epidemiological observations suggest that T cell immunity may be suppressed in malaria-endemic areas. In vitro studies, animal models, and limited data in humans link immunosuppression with malaria, malnutrition, and other parasitic infections. However, there are no data to determine whether malaria-induced immunosuppression is significant in the long-term, or relative data comparing it with other factors in malaria-endemic areas, so as to measure the impact of malaria, other parasitic disease, nutritional status, age. and location on the acquisition and longevity of IFN-gamma responses in children in Kenya. We studied these factors in two cohorts of 1- to 6-year-old children in a malaria-endemic area. T cell responses were induced by vaccination in one cohort, and acquired as a result of natural exposure in a second cohort. Serial ELISPOT assays conducted over a 1-year period measured the induction and kinetics of IFN-gamma production in response to the malaria Ag thrombospondin-related adhesion protein. Induced responses in both cohorts and the longevity of response in the vaccinated cohort were fitted to potential explanatory variables. Parasitemia was prospectively associated with reduced IFN-gamma-producing T cells in both cohorts (by 15-25%), and both parasitemia and episodes of febrile malaria were associated with 19 and 31% greater attrition of T cell responses, respectively. Malaria may reduce the efficacy vaccinations such as bacillus Calmette-Guérin and investigational T cell-inducing vaccines, and may delay the acquisition of immunity following natural exposure to malaria and other pathogens.

Publication status:: Published

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APA Style

Bejon, P., Mwacharo, J., Kai, O., Todryk, S., Keating, S., Lowe, B., Lang, T., Mwangi, T., Gilbert, S., Peshu, N., Marsh, K., & Hill, A. (2007). The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparum. Journal of Immunology, 179(6), 4193–4201.

MLA Style

Bejon, P, et al. “The Induction and Persistence of T Cell IFN-Gamma Responses after Vaccination or Natural Exposure Is Suppressed by Plasmodium Falciparum.” Journal of Immunology, vol. 179, no. 6, 2007, pp. 4193–201.

Chicago Style

Bejon, P, J Mwacharo, O Kai, et al. 2007. “The Induction and Persistence of T Cell IFN-Gamma Responses after Vaccination or Natural Exposure Is Suppressed by Plasmodium Falciparum.” Journal of Immunology 179 (6): 4193–4201.
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