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Journal article

Compartmentalizing acid stress in bacteria

Abstract:
A Donnan equilibrium causes an influx of chloride ions into the Escherichia coli periplasm when the bacterium finds itself in gastric fluid. The combination of low pH and high anion concentration drives proteins to aggregate, a potentially lethal event unless prevented by specific chaperones.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41589-018-0148-7

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
ORCID:
0000-0002-3273-0302
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Chemical Biology Journal website
Volume:
14
Issue:
11
Pages:
993-994
Publication date:
2018-10-15
Acceptance date:
2018-09-14
DOI:
EISSN:
1552-4469
ISSN:
1552-4450
Pubs id:
pubs:934991
URN:
uri:8ee44655-c3ab-4f8e-a8dd-e670515c848b
UUID:
uuid:8ee44655-c3ab-4f8e-a8dd-e670515c848b
Local pid:
pubs:934991
Language:
English

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