AMP-activated protein kinase as a target for preconditioning in transplantation medicine.

Journal article

Graft quality before transplantation is a major factor influencing chronic rejection. Organ preservation and ischemia/reperfusion play an important role in the induction of organ injury. Although both suppression of metabolism by hypothermic preservation and preconditioning before ischemia limit injury, understanding the biochemical signaling pathways will allow us to optimize graft preservation further. Adenosine monophosphate-activated protein kinase (AMPK) is an important enzyme sensing ce...

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Authors: Bouma, H; Ketelaar, M; Yard, B; Ploeg, R; Henning, R

• Publication status: Published
• Journal: Transplantation
• Volume: 90
• Issue: 4
• Pages: 353-358
• Publication date: 2010-08-01
• DOI: 10.1097/tp.0b013e3181e7a3aa
• EISSN: 1534-6080
• ISSN: 0041-1337
• Language: English
• Keywords: Humans; Energy Metabolism; Calcium; Graft Rejection; Receptors, Purinergic P1; Cytosol; Adenosine; Reperfusion Injury; Hypoxanthine; Ischemic Preconditioning; Mice; Transplantation; Sodium-Potassium-Exchanging ATPase; Animals; AMP-Activated Protein Kinases; Signal Transduction