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Journal article

New insights into the evolutionary rate of HIV-1 at the within-host and epidemiological levels.

Abstract:

Over calendar time, HIV-1 evolves considerably faster within individuals than it does at the epidemic level. This is a surprising observation since, from basic population genetic theory, we would expect the genetic substitution rate to be similar across different levels of biological organization. Three different mechanisms could potentially cause the observed mismatch in phylogenetic rates of divergence: temporal changes in selection pressure during the course of infection; frequent reversio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
ORCID:
0000-0002-7089-7680
More by this author
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
ORCID:
0000-0003-2399-9657
More from this funder
Name:
Wellcome Trust
Funder identifier:
http://dx.doi.org/10.13039/100010269
Funding agency for:
Lythgoe, KA
More from this funder
Name:
Royal Society
Funder identifier:
http://dx.doi.org/10.13039/501100000288
Funding agency for:
Fraser, C
More from this funder
Name:
Medical Research Council
Funding agency for:
Fraser, C
Publisher:
The Royal Society
Journal:
Proceedings of the Royal Society B: Biological Sciences More from this journal
Volume:
279
Issue:
1741
Pages:
3367-3375
Place of publication:
England
Publication date:
2012-05-16
Acceptance date:
2012-04-23
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
Pmid:
22593106
Language:
English
Keywords:
Pubs id:
641573
Local pid:
pubs:641573
Deposit date:
2020-06-22

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