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Genomic evolution of breast cancer metastasis and relapse.

Abstract:

Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel of 365 genes on 299 samples from 170 patients with locally relapsed or metastatic breast cancer. Several lines of analysis indicate that clones seeding metastasis or relapse disseminate late from primary tumors, but continue to acquire mutations, mostly accessing the same ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Name:
Medical Research Council
Grant:
FC001202
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Name:
Cancer Research UK
Grant:
FC001202
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Name:
Wellcome Trust
Grant:
FC001202
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Name:
Netherlands Organisation for Scientific Research
Publisher:
Elsevier
Journal:
Cancer Cell More from this journal
Volume:
32
Issue:
2
Pages:
169-184.e7
Publication date:
2017-08-01
Acceptance date:
2017-07-14
DOI:
ISSN:
1878-3686 and 1535-6108
Pmid:
28810143
Language:
English
Keywords:
Pubs id:
pubs:713680
UUID:
uuid:8ed34bcc-58ae-4b89-8a5c-4a7c3274f749
Local pid:
pubs:713680
Source identifiers:
713680
Deposit date:
2017-08-25

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