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Use of synthetic peptides of influenza nucleoprotein to define epitopes recognized by class I-restricted cytotoxic T lymphocytes.

Abstract:

The conserved epitopes of influenza nucleoprotein (NP) recognized by class I MHC-restricted CTL from CBA (H-2k) and C57BL/10 (H-2b) mice have been defined in vitro with synthetic peptides 50-63 and 365-379, respectively. Two Db-restricted clones were described that recognize different epitopes on peptide 365-379. Finally, the recognition of complete NP was shown to be approximately 200-fold less efficient than peptide in the cytotoxicity assay. These phenomena are closely related to results w...

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Publication status:
Published

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Publisher copy:
10.1084/jem.165.6.1508

Authors


Rothbard, J More by this author
Townsend, A More by this author
Journal:
The Journal of experimental medicine
Volume:
165
Issue:
6
Pages:
1508-1523
Publication date:
1987-06-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:8ec6f844-1c9b-49d8-bd8b-a2bb00683fdf
Source identifiers:
72168
Local pid:
pubs:72168

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