- Abstract:
-
The lymphatic vessel endothelial receptor LYVE-1 is implicated in uptake of hyaluronan (HA) and trafficking of leucocytes to draining lymph nodes. Yet LYVE-1 has only weak affinity for hyaluronan, and depends on receptor clustering and higher-order ligand organisation for durable binding in lymphatic endothelium. An unusual feature of LYVE-1 not found in other HA receptors is the potential to form disulfide-linked homodimers. However their influence on function has not been investigated. Here...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.7mb)
-
- Publisher copy:
- 10.1074/jbc.M116.736926
-
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- Grant:
- MRC Human Immunology Unit (DGJ); G9826026 (CM)
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Volume:
- 291
- Issue:
- 48
- Pages:
- 25004-25018
- Publication date:
- 2016
- Acceptance date:
- 2016-10-12
- DOI:
- ISSN:
-
1083-351X
- Pubs id:
-
pubs:655993
- URN:
-
uri:8eb19a7c-c3bf-4c15-b40a-55d7e6980489
- UUID:
-
uuid:8eb19a7c-c3bf-4c15-b40a-55d7e6980489
- Local pid:
- pubs:655993
- Copyright holder:
- American Society for Biochemistry and Molecular Biology
- Copyright date:
- 2016
- Notes:
- Copyright © 2016, The American Society for Biochemistry and Molecular Biology. This is the accepted manuscript version of the article. Final version free via Creative Commons CC-BY license.
Journal article
Homodimerisation of the lymph vessel endothelial receptor LYVE-1 through a redox-labile disulfide is critical for hyaluronan binding in lymphatic endothelium
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