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Homodimerisation of the lymph vessel endothelial receptor LYVE-1 through a redox-labile disulfide is critical for hyaluronan binding in lymphatic endothelium

Abstract:

The lymphatic vessel endothelial receptor LYVE-1 is implicated in uptake of hyaluronan (HA) and trafficking of leucocytes to draining lymph nodes. Yet LYVE-1 has only weak affinity for hyaluronan, and depends on receptor clustering and higher-order ligand organisation for durable binding in lymphatic endothelium. An unusual feature of LYVE-1 not found in other HA receptors is the potential to form disulfide-linked homodimers. However their influence on function has not been investigated. Here...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1074/jbc.M116.736926

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Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Lawrance, W More by this author
Metcalfe, C More by this author
Briggs, DC More by this author
Yamauchi, A More by this author
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Grant:
MRC Human Immunology Unit (DGJ); G9826026 (CM)
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
291
Issue:
48
Pages:
25004-25018
Publication date:
2016
Acceptance date:
2016-10-12
DOI:
ISSN:
1083-351X
Pubs id:
pubs:655993
URN:
uri:8eb19a7c-c3bf-4c15-b40a-55d7e6980489
UUID:
uuid:8eb19a7c-c3bf-4c15-b40a-55d7e6980489
Local pid:
pubs:655993

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