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Journal article

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil

Abstract:
Introduction Synapse loss is the structural correlate of the cognitive decline indicative of dementia. In the brains of Alzheimer's disease sufferers, amyloid β (Aβ) peptides aggregate to form senile plaques but as soluble peptides are toxic to synapses. We previously demonstrated that Aβ induces Dickkopf-1 (Dkk1), which in turn activates the Wnt–planar cell polarity (Wnt-PCP) pathway to drive tau pathology and neuronal death. Methods We compared the effects... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jalz.2017.09.008

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Role:
Author
ORCID:
0000-0002-2838-8612
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Alzheimer's and Dementia Journal website
Volume:
14
Issue:
3
Pages:
306-317
Publication date:
2017-10-19
Acceptance date:
2017-11-07
DOI:
EISSN:
1552-5279
ISSN:
1552-5260
Pubs id:
pubs:742118
URN:
uri:8ea7a1d9-0656-4ec8-a632-71606a6521f2
UUID:
uuid:8ea7a1d9-0656-4ec8-a632-71606a6521f2
Local pid:
pubs:742118

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