- Abstract:
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Introduction Synapse loss is the structural correlate of the cognitive decline indicative of dementia. In the brains of Alzheimer's disease sufferers, amyloid β (Aβ) peptides aggregate to form senile plaques but as soluble peptides are toxic to synapses. We previously demonstrated that Aβ induces Dickkopf-1 (Dkk1), which in turn activates the Wnt–planar cell polarity (Wnt-PCP) pathway to drive tau pathology and neuronal death. Methods We compared the effects... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 2.6MB)
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- Publisher copy:
- 10.1016/j.jalz.2017.09.008
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Alzheimer's and Dementia Journal website
- Volume:
- 14
- Issue:
- 3
- Pages:
- 306-317
- Publication date:
- 2017-10-19
- Acceptance date:
- 2017-11-07
- DOI:
- EISSN:
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1552-5279
- ISSN:
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1552-5260
- Pubs id:
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pubs:742118
- URN:
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uri:8ea7a1d9-0656-4ec8-a632-71606a6521f2
- UUID:
-
uuid:8ea7a1d9-0656-4ec8-a632-71606a6521f2
- Local pid:
- pubs:742118
- Language:
- English
- Keywords:
- Copyright holder:
- Sellers et al.
- Copyright date:
- 2017
- Notes:
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Copyright © 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).
Journal article
Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil
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