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A new multipoint method for genome-wide association studies by imputation of genotypes.

Abstract:

Genome-wide association studies are set to become the method of choice for uncovering the genetic basis of human diseases. A central challenge in this area is the development of powerful multipoint methods that can detect causal variants that have not been directly genotyped. We propose a coherent analysis framework that treats the problem as one involving missing or uncertain genotypes. Central to our approach is a model-based imputation method for inferring genotypes at observed or unobserv...

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Publication status:
Published

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Publisher copy:
10.1038/ng2088

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics, Clinical Medicine
Donnelly, P More by this author
Journal:
Nature genetics
Volume:
39
Issue:
7
Pages:
906-913
Publication date:
2007-07-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:8ea21099-f9b9-4acf-93ed-4f98659e1517
Source identifiers:
49987
Local pid:
pubs:49987

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