Journal article
A new multipoint method for genome-wide association studies by imputation of genotypes.
- Abstract:
-
Genome-wide association studies are set to become the method of choice for uncovering the genetic basis of human diseases. A central challenge in this area is the development of powerful multipoint methods that can detect causal variants that have not been directly genotyped. We propose a coherent analysis framework that treats the problem as one involving missing or uncertain genotypes. Central to our approach is a model-based imputation method for inferring genotypes at observed or unobserv...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/ng2088
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Authors
Bibliographic Details
- Journal:
- Nature genetics
- Volume:
- 39
- Issue:
- 7
- Pages:
- 906-913
- Publication date:
- 2007-07-01
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Source identifiers:
-
49987
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:49987
- UUID:
-
uuid:8ea21099-f9b9-4acf-93ed-4f98659e1517
- Local pid:
- pubs:49987
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2007
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