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Lipid and glucose metabolism in hepatocyte cell lines and primary mouse hepatocytes: A comprehensive resource for in vitro studies of hepatic metabolism

Abstract:

The liver is a critical tissue for maintaining glucose, fatty acid, and cholesterol homeostasis. Primary hepatocytes represent the gold standard for studying the mechanisms controlling hepatic glucose, lipid, and cholesterol metabolism in vitro. However, access to primary hepatocytes can be limiting, and therefore, other immortalized hepatocyte models are commonly used. Here, we describe substrate metabolism of cultured AML12, IHH, and PH5CH8 cells, hepatocellular carcinoma-derived HepG2s, an...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1152/ajpendo.00365.2018

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Publisher:
American Physiological Society
Journal:
AJP - Endocrinology and Metabolism More from this journal
Volume:
316
Issue:
4
Pages:
E578-E589
Publication date:
2019-04-01
Acceptance date:
2019-01-24
DOI:
EISSN:
1522-1555
ISSN:
0193-1849
Language:
English
Keywords:
Pubs id:
1088725
Local pid:
pubs:1088725
Deposit date:
2020-02-24

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