Journal article
Acyclic quaternary centers from asymmetric conjugate addition of alkylzirconium reagents to linear trisubstituted enones
- Abstract:
-
Synthetic methods for the selective formation of all carbon quaternary centres in non-cyclic systems are rare. Here we report highly enantioselective Cu-catalytic asymmetric conjugate addition of alkylzirconium species to twelve different acyclic trisubstituted enones. A variety of sp(3)-hybridized nucleophiles generated by in situ hydrozirconation of alkenes with the Schwartz reagent can be introduced, giving linear products bearing quaternary centres with up to 98% ee. The method is toleran...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 571.0KB)
-
- Publisher copy:
- 10.1039/c6sc02811j
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Fletcher, S
Grant:
EP/H003711/1/
Bibliographic Details
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical Science Journal website
- Volume:
- 8
- Issue:
- 1
- Pages:
- 641-646
- Publication date:
- 2016-09-02
- Acceptance date:
- 2016-09-01
- DOI:
- EISSN:
-
2041-6539
- ISSN:
-
2041-6520
- Source identifiers:
-
670818
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:670818
- UUID:
-
uuid:8e9d7732-e40d-43b6-aa23-557264a368af
- Local pid:
- pubs:670818
- Deposit date:
- 2017-06-02
Terms of use
- Copyright holder:
- © 2017 Gao & Fletcher
- Copyright date:
- 2016
- Notes:
- Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
If you are the owner of this record, you can report an update to it here: Report update to this record