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Manipulation of indoleamine 2,3-dioxygenase (IDO) for clinical transplantation: promises and challenges

Abstract:

Background: Since the discovery that indoleamine 2,3-dioxygenase (IDO) is a modulator for maintenance of fetomaternal immuno-privilege state, it has been implicated in tumour tolerance, autoimmune diseases and asthma. IDO is an IFN-γ-inducible, intracellular enzyme that catalyzes the initial and rate-limiting step in the degradation of tryptophan. It has been suggested that IDO can regulate the immune system either through deprivation of tryptophan that is essential for T cell proliferation o...

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Publication status:
Published

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Publisher copy:
10.1517/14712590802472077

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
EXPERT OPINION ON BIOLOGICAL THERAPY More from this journal
Volume:
8
Issue:
11
Pages:
1705-1719
Publication date:
2008-11-01
DOI:
ISSN:
1471-2598
Language:
English
Keywords:
Pubs id:
pubs:145333
UUID:
uuid:8e92bf3b-299c-46c5-a4df-ab6674b1614c
Local pid:
pubs:145333
Source identifiers:
145333
Deposit date:
2012-12-19

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