Journal article : Review
A dynamical paradigm for molecular cell biology
- Abstract:
- The driving passion of molecular cell biologists is to understand the molecular mechanisms that control important aspects of cell physiology, but this ambition is often limited by the wealth of molecular details currently known about these mechanisms. Their complexity overwhelms our intuitive notions of how molecular regulatory networks might respond under normal and stressful conditions. To make progress we need a new paradigm for connecting molecular biology to cell physiology. We suggest an approach that uses precise mathematical methods to associate the qualitative features of dynamical systems, as conveyed by 'bifurcation diagrams', with 'signal–response' curves measured by cell biologists.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1016/j.tcb.2020.04.002
Authors
- Publisher:
- Cell Press
- Journal:
- Trends in Cell Biology More from this journal
- Volume:
- 30
- Issue:
- 7
- Pages:
- 504-515
- Publication date:
- 2020-04-30
- Acceptance date:
- 2020-04-01
- DOI:
- EISSN:
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1879-3088
- ISSN:
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0962-8924
- Pmid:
-
32362451
- Language:
-
English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1103748
- Local pid:
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pubs:1103748
- Deposit date:
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2020-06-08
- ARK identifier:
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2020
- Rights statement:
- © 2020 Elsevier Ltd.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Cell Press at https://doi.org/10.1016/j.tcb.2020.04.002
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