Journal article icon

Journal article

The role of protein structural analysis in the next generation sequencing era

Abstract:

Proteins are macromolecules that serve a cell's myriad processes and functions in all living organisms via dynamic interactions with other proteins, small molecules and cellular components. Genetic variations in the protein-encoding regions of the human genome account for >85% of all known Mendelian diseases, and play an influential role in shaping complex polygenic diseases. Proteins also serve as the predominant target class for the design of small molecule drugs to modulate their activi...

Expand abstract

Actions


Access Document


Publisher copy:
10.1007/128-2012-326

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Journal:
Topics in Current Chemistry
Volume:
336
Pages:
67-98
Publication date:
2014-01-01
DOI:
ISSN:
0340-1022
Source identifiers:
446500
Language:
English
Keywords:
Pubs id:
pubs:446500
UUID:
uuid:8e91cd12-453a-487d-bd58-31edb35f0546
Local pid:
pubs:446500
Deposit date:
2014-02-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP