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The role of protein structural analysis in the next generation sequencing era

Abstract:

Proteins are macromolecules that serve a cell's myriad processes and functions in all living organisms via dynamic interactions with other proteins, small molecules and cellular components. Genetic variations in the protein-encoding regions of the human genome account for >85% of all known Mendelian diseases, and play an influential role in shaping complex polygenic diseases. Proteins also serve as the predominant target class for the design of small molecule drugs to modulate their activi...

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Publisher copy:
10.1007/128-2012-326

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
Journal:
Topics in Current Chemistry
Volume:
336
Pages:
67-98
Publication date:
2014-01-01
DOI:
ISSN:
0340-1022
URN:
uuid:8e91cd12-453a-487d-bd58-31edb35f0546
Source identifiers:
446500
Local pid:
pubs:446500

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