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Journal article

High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment

Abstract:

OBJECTIVES: HIV-1 integrase inhibitors are recommended as first-line therapy by WHO, though efficacy and resistance data for non-B subtypes are limited. Two recent trials have identified the integrase L74I mutation to be associated with integrase inhibitor treatment failure in HIV-1 non-B subtypes. We sought to define the prevalence of integrase resistance mutations, including L74I, in West Africa.

METHODS: We studied a Nigerian cohort of recipient...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/jac/dkaa033

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Role:
Author
ORCID:
0000-0003-0521-2144
Publisher:
Oxford University Press
Journal:
Journal of Antimicrobial Chemotherapy More from this journal
Volume:
75
Issue:
6
Pages:
1575-1579
Publication date:
2020-02-27
Acceptance date:
2020-01-16
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
Pmid:
32105319
Language:
English
Keywords:
Pubs id:
1094655
Local pid:
pubs:1094655
Deposit date:
2021-01-09

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