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Journal article

Transcriptional modulation of human endogenous retroviruses in primary CD4+ T xells following vorinostat treatment

Abstract:

The greatest obstacle to a cure for HIV is the provirus that integrates into the genome of the infected cell and persists despite antiretroviral therapy. A “shock and kill” approach has been proposed as a strategy for an HIV cure whereby drugs and compounds referred to as latency-reversing agents (LRAs) are used to “shock” the silent provirus into active replication to permit “killing” by virus-induced pathology or immune recognition. The LRA most utilized to date in clinical trials has been ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.3389/fimmu.2018.00603

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Publisher:
Frontiers Research Foundation Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Chapter number:
603
Publication date:
2018-04-12
Acceptance date:
2018-03-09
DOI:
EISSN:
1664-3224
Pubs id:
pubs:844231
URN:
uri:8e82dfee-ffe8-477f-8bf6-959f3fef0c81
UUID:
uuid:8e82dfee-ffe8-477f-8bf6-959f3fef0c81
Local pid:
pubs:844231

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