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A functional human IgM response to HIV-1 Env after immunization with NYVAC HIV C.

Abstract:
Env-specific IgG and IgM were detected in 25 and 60%, respectively, of volunteers immunized with NYVAC expressing clade C gp120. The serum sample with the highest IgM titre but undetectable IgG neutralized the homologous isolate with a reciprocal IC90 titre of 7.8 in the absence of complement, and 24.4 in the presence of complement (P = 0.0003). These results suggest that vaccine-induced, Env-specific IgM may have antiviral activity and should be subjected to further investigation.
Publication status:
Published

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Authors


Sheppard, NC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
AIDS (London, England)
Volume:
21
Issue:
4
Pages:
524-527
Publication date:
2007-02-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:8e71e161-d7e0-483c-a4a6-5bee68db2f90
Source identifiers:
28425
Local pid:
pubs:28425

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