- Abstract:
- Env-specific IgG and IgM were detected in 25 and 60%, respectively, of volunteers immunized with NYVAC expressing clade C gp120. The serum sample with the highest IgM titre but undetectable IgG neutralized the homologous isolate with a reciprocal IC90 titre of 7.8 in the absence of complement, and 24.4 in the presence of complement (P = 0.0003). These results suggest that vaccine-induced, Env-specific IgM may have antiviral activity and should be subjected to further investigation.
- Publication status:
- Published
- Publisher copy:
- 10.1097/qad.0b013e32803277f9
-
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- Journal:
- AIDS (London, England)
- Volume:
- 21
- Issue:
- 4
- Pages:
- 524-527
- Publication date:
- 2007-02-05
- DOI:
- EISSN:
-
1473-5571
- ISSN:
-
0269-9370
- URN:
-
uuid:8e71e161-d7e0-483c-a4a6-5bee68db2f90
- Source identifiers:
-
28425
- Local pid:
- pubs:28425
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
A functional human IgM response to HIV-1 Env after immunization with NYVAC HIV C.
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