- Abstract:
-
CD4(+) regulatory T cells have been shown to prevent intestinal inflammation; however, it is not known whether they act to prevent the priming of colitogenic T cells or actively control these cells as part of the memory T cell pool. In this study, we describe the presence of colitogenic Th1 cells within the CD4(+)CD45RB(low) population. These pathogenic cells enrich within the CD25(-) subset and are not recent thymic emigrants. CD4(+)CD45RB(low) cells from germfree mice were significantly red...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4049/jimmunol.171.2.971
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 171
- Issue:
- 2
- Pages:
- 971-978
- Publication date:
- 2003-07-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:8e4e9000-a261-47ef-b513-6084cfe4baca
- Source identifiers:
-
2514
- Local pid:
- pubs:2514
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10.
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