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Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10.

Abstract:

CD4(+) regulatory T cells have been shown to prevent intestinal inflammation; however, it is not known whether they act to prevent the priming of colitogenic T cells or actively control these cells as part of the memory T cell pool. In this study, we describe the presence of colitogenic Th1 cells within the CD4(+)CD45RB(low) population. These pathogenic cells enrich within the CD25(-) subset and are not recent thymic emigrants. CD4(+)CD45RB(low) cells from germfree mice were significantly red...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.171.2.971

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Journal:
Journal of Immunology
Volume:
171
Issue:
2
Pages:
971-978
Publication date:
2003-07-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
2514

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