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The natural history of multiple sclerosis: a geographically based study. 5. The clinical features and natural history of primary progressive multiple sclerosis.

Abstract:

We report a natural history study of 216 patients with primary progressive (PP)- multiple sclerosis defined by at least 1 year of exacerbation-free progression at onset. This represents 19.8% of a largely population-based patient cohort having a mean longitudinal follow-up of 23 years. This subgroup of PP-multiple sclerosis patients had a mean age of onset of 38.5 years, with females predominating by a ratio of 1.3:1.0. The rate of deterioration from disease onset was substantially more rapid...

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Publication status:
Published

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Publisher copy:
10.1093/brain/122.4.625

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Journal:
Brain : a journal of neurology More from this journal
Volume:
122 ( Pt 4)
Issue:
4
Pages:
625-639
Publication date:
1999-04-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
pubs:31468
UUID:
uuid:8e2706ee-1c09-48f0-9dc1-9247f60377a0
Local pid:
pubs:31468
Source identifiers:
31468
Deposit date:
2012-12-19

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