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Comparison of CID versus ETD based MS/MS fragmentation for the analysis of protein ubiquitination.

Abstract:

Ubiquitination has emerged as one of the major post-translational modifications that decide on protein fate, targeting, and regulation of protein function. Whereas the ubiquitination of proteins can be monitored with classic biochemical methods, the mapping of modified side chains proves to be challenging. More recently, mass spectrometry has been applied to identify ubiquitinated proteins and also their sites of modification. Typically, liquid chromatography tandem mass spectrometry (LC-MS/M...

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Publication status:
Published

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Publisher copy:
10.1016/j.jasms.2009.04.023

Authors


Journal:
Journal of the American Society for Mass Spectrometry
Volume:
20
Issue:
9
Pages:
1652-1659
Publication date:
2009-09-01
DOI:
EISSN:
1879-1123
ISSN:
1044-0305
Language:
English
Keywords:
Pubs id:
pubs:1942
UUID:
uuid:8e0f7611-51c5-4262-a426-19b6e9f3fc16
Local pid:
pubs:1942
Source identifiers:
1942
Deposit date:
2012-12-19

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