- Abstract:
-
SHP-2 (Src homology phosphatase type-2) is essential for haematopoietic skeletal and vascular development. Thus the identification of its binding partners is critically important. In the present study, we describe a unique monoclonal antibody, WM78, which interacts with PZR, a SHP-2 binding partner. Furthermore, we identify two novel isoforms of PZR, PZRa and PZRb, derived by differential splicing from a single gene transcription unit on human chromosome 1q24. All are type 1 transmembrane gly...
Expand abstract - Publisher copy:
- 10.1042/bj20020935
-
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- Journal:
- The Biochemical journal
- Volume:
- 370
- Issue:
- Pt 2
- Pages:
- 537-549
- Publication date:
- 2003-03-05
- DOI:
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- URN:
-
uuid:8df1f5d8-2ed4-4c5d-b933-5746a85ef955
- Source identifiers:
-
102523
- Local pid:
- pubs:102523
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration.
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