Journal article icon

Journal article

Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration.

Abstract:

SHP-2 (Src homology phosphatase type-2) is essential for haematopoietic skeletal and vascular development. Thus the identification of its binding partners is critically important. In the present study, we describe a unique monoclonal antibody, WM78, which interacts with PZR, a SHP-2 binding partner. Furthermore, we identify two novel isoforms of PZR, PZRa and PZRb, derived by differential splicing from a single gene transcription unit on human chromosome 1q24. All are type 1 transmembrane gly...

Expand abstract

Actions


Access Document


Publisher copy:
10.1042/bj20020935

Authors


Expand authors...
Journal:
The Biochemical journal
Volume:
370
Issue:
Pt 2
Pages:
537-549
Publication date:
2003-03-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:8df1f5d8-2ed4-4c5d-b933-5746a85ef955
Source identifiers:
102523
Local pid:
pubs:102523

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP