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P-TEFb goes viral

Abstract:

Positive transcription elongation factor b (P-TEFb), which comprises cyclin-dependent kinase 9 (CDK9) kinase and cyclin T subunits, is an essential kinase complex in human cells. Phosphorylation of the negative elongation factors by P-TEFb is required for productive elongation of transcription of protein-coding genes by RNA polymerase II (pol II). In addition, P-TEFb-mediated phosphorylation of the carboxyl-terminal domain (CTD) of the largest subunit of pol II mediates the recruitment of tra...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/icl3.1037

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More from this funder
Name:
Sir Edward Penley Abraham Trust Fund
Funding agency for:
Murphy, S
Grant:
EPA-RF202
More from this funder
Name:
Wellcome Trust
Funding agency for:
Murphy, S
Grant:
EPA-RF202
More from this funder
Name:
Malaysian Government
Funding agency for:
Isa, N
Publisher:
Wiley
Journal:
Inside the Cell More from this journal
Pages:
n/a-n/a
Publication date:
2015-01-01
DOI:
ISSN:
2375-2920
Keywords:
Pubs id:
pubs:598610
UUID:
uuid:8ded2912-beb8-4ddc-bf96-b1c830f4d4a4
Local pid:
pubs:598610
Source identifiers:
598610
Deposit date:
2016-02-02

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