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Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus

Abstract:

Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in young children globally, but little is known about within-host RSV diversity. Here, we characterised within-host RSV populations using deep-sequencing data from 319 nasopharyngeal swabs collected during 2017-2020. RSV-B had lower consensus diversity than RSV-A at the population level, while exhibiting greater within-host diversity. Two RSV-B consensus sequences had an amino acid alteration (K68N) ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-25265-4

Authors


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Role:
Author
ORCID:
0000-0002-9950-318X
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Role:
Author
ORCID:
0000-0002-6350-6557
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Institution:
University of Oxford
Division:
MSD
Sub department:
Paediatrics
Role:
Author
ORCID:
0000-0002-6902-9886
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Role:
Author
ORCID:
0000-0001-6751-3300

Contributors

Role:
Contributor
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Name:
Innovative Medicines Initiative (IMI)
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
12
Issue:
1
Article number:
5125
Publication date:
2021-08-26
Acceptance date:
2021-07-21
DOI:
EISSN:
2041-1723
Pmid:
34446722
Language:
English
Keywords:
Pubs id:
1193181
Local pid:
pubs:1193181
Deposit date:
2021-09-10

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