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trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase

Abstract:

Mutants of trt-1, the Caenorhabditis elegans telomerase reverse transcriptase, reproduce normally for several generations but eventually become sterile as a consequence of telomere erosion and end-to-end chromosome fusions. Telomere erosion and uncapping do not cause an increase in apoptosis in the germlines of trt-1 mutants. Instead, lategeneration trt-1 mutants display chromosome segregation defects that are likely to be the direct cause of sterility. trt-1 functions in the same telomere re...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.0020018

Authors


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Institution:
University of Dundee
Department:
Wellcome Trust Biocenter
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Institution:
University of North Carolina
Department:
Lineberger Comprehensive Cancer Center
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Institution:
University of North Carolina
Department:
Department of Genetics
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Institution:
University of North Carolina
Department:
Department of Biology
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Institution:
University of Dundee
Department:
Wellcome Trust Biocenter
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Contributors

Institution:
Stanford University
Role:
Editor
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Funding agency for:
Anton Gartner
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
2
Issue:
2
Pages:
Article: e18
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:8dd0cf96-6a30-422e-99a6-0c0dfced78d4
Local pid:
ora:966
Language:
English
Keywords:
Subjects:

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