trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
Mutants of trt-1, the Caenorhabditis elegans telomerase reverse transcriptase, reproduce normally for several generations but eventually become sterile as a consequence of telomere erosion and end-to-end chromosome fusions. Telomere erosion and uncapping do not cause an increase in apoptosis in the germlines of trt-1 mutants. Instead, lategeneration trt-1 mutants display chromosome segregation defects that are likely to be the direct cause of sterility. trt-1 functions in the same telomere re...Expand abstract
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- Meier, B., Clejan, I., Liu, Y. et al.
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This article was published by PLos as: Meier B, Clejan I, Liu Y, Lowden M, Gartner A, et al. (2006) trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase. PLoS Genet 2(2): e18. This is an open-access article distributed under the terms of the Creative Commons
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