Mutants of trt-1, the Caenorhabditis elegans telomerase reverse transcriptase, reproduce normally for several generations but eventually become sterile as a consequence of telomere erosion and end-to-end chromosome fusions. Telomere erosion and uncapping do not cause an increase in apoptosis in the germlines of trt-1 mutants. Instead, lategeneration trt-1 mutants display chromosome segregation defects that are likely to be the direct cause of sterility. trt-1 functions in the same telomere re...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher's version
- Funding agency for:
- Iuval Clejan
- Copyright holder:
- Meier, B., Clejan, I., Liu, Y. et al.
- Copyright date:
This article was published by PLos as: Meier B, Clejan I, Liu Y, Lowden M, Gartner A, et al. (2006) trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase. PLoS Genet 2(2): e18. This is an open-access article distributed under the terms of the Creative Commons
Public Domain declaration which stipulates that, once placed in the public domain,
this work may be freely reproduced, distributed, transmitted, modified, built upon,
or otherwise used by anyone for any lawful purpose.