Journal article
Electroencephalographic features of convulsive epilepsy in Africa: a multicentre study of prevalence, pattern and associated factors
- Abstract:
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Objective: We investigated the prevalence and pattern of electroencephalographic (EEG) features of epilepsy and the associated factors in Africans with active convulsive epilepsy (ACE).
Methods: We characterized electroencephalographic features and determined associated factors in a sample of people with ACE in five African sites. Mixed-effects modified Poisson regression model was used to determine factors associated with abnormal EEGs.
Results: Recordings were performed on 1426 people of whom 751 (53%) had abnormal EEGs, being an adjusted prevalence of 2.7 (95% confidence interval (95% CI), 2.5–2.9) per 1000. 52% of the abnormal EEG had focal features (75% with temporal lobe involvement). The frequency and pattern of changes differed with site. Abnormal EEGs were associated with adverse perinatal events (risk ratio (RR) = 1.19 (95% CI, 1.07–1.33)), cognitive impairments (RR = 1.50 (95% CI, 1.30–1.73)), use of anti-epileptic drugs (RR = 1.25 (95% CI, 1.05–1.49)), focal seizures (RR = 1.09 (95% CI, 1.00–1.19)) and seizure frequency (RR = 1.18 (95% CI, 1.10–1.26) for daily seizures; RR = 1.22 (95% CI, 1.10–1.35) for weekly seizures and RR = 1.15 (95% CI, 1.03–1.28) for monthly seizures)).
Conclusions: EEG abnormalities are common in Africans with epilepsy and are associated with preventable risk factors.
Significance: EEG is helpful in identifying focal epilepsy in Africa, where timing of focal aetiologies is problematic and there is a lack of neuroimaging services.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 633.1KB, Terms of use)
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- Publisher copy:
- 10.1016/j.clinph.2015.07.033
Authors
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 092654/Z/10/A
- 083744/B/07/C
- 099782/Z/12/Z
- Publisher:
- Elsevier
- Journal:
- Clinical Neurophysiology More from this journal
- Volume:
- 127
- Issue:
- 2
- Pages:
- 1099-1107
- Publication date:
- 2015-08-20
- Acceptance date:
- 2015-07-28
- DOI:
- EISSN:
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1872-8952
- ISSN:
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1388-2457
- Pmid:
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26337840
- Language:
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English
- Keywords:
- Pubs id:
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545767
- Local pid:
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pubs:545767
- Deposit date:
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2024-11-23
- ARK identifier:
Terms of use
- Copyright holder:
- International Federation of Clinical Neurophysiology
- Copyright date:
- 2015
- Rights statement:
- © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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