Role of repetitive antigen patterns for induction of antibodies against antibodies.

Journal article

Antibody responses against antibodies, such as rheumatoid factors, are found in several immunopathological diseases and may play a role in disease pathogenesis. Experience shows that they are usually difficult to induce experimentally. Antibodies specific for immunoglobulin constant regions (anti-allotypic) or for variable regions (anti-idiotypic) have been investigated in animal models; the latter have even been postulated to regulate antibody and T cell responses via network-like interactio...

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Authors: Fehr, T; Bachmann, M; Bucher, E; Kalinke, U; Di Padova, F

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 185
• Issue: 10
• Pages: 1785-1792
• Publication date: 1997-05-01
• DOI: 10.1084/jem.185.10.1785
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Cell Line; Animals; O Antigens; Immunoglobulin M; Mice, Inbred BALB C; Mice; Autoantibodies; Antibodies, Monoclonal; Membrane Glycoproteins; Immunoglobulin Idiotypes; Pseudomonas aeruginosa; Immunoglobulin Allotypes; Vesicular stomatitis Indiana virus; Immunoglobulin Variable Region; Antibody Formation; Immunoglobulin Constant Regions; Cricetinae; Recombinant Fusion Proteins; Viral Envelope Proteins; Antibodies, Anti-Idiotypic; Epitopes; Immunoglobulin G